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NR 565 Exam Final Study Guide  Antacids: weak bases that react with hydrochloric acid to form salt & water. o Used in the treatment of Hyperacidity, GERD, PUD, hyperphosphatemia, and calcium defi... ciency o Contain combinations of  metallic cation (aluminum, calcium, magnesium, and sodium)  and basic anion (hydroxide, bicarbonate, carbonate, citrate, and trisilicate)  Pharmacodynamics, Pharmacokinetics, Pharmacotherapeutics o Neutralize Gastric Acidity (causes ^pH of the stomach and duodenal bulb) o Inhibit proteolytic activity of pepsin o Increase lower esophageal sphincter tone o Acid-neutralizing capacity ANC varies between products expressed in mEqs o If ingested in a fasting state, antacids reduce acidity for approximately 20 to 40 minutes o If taken 1 hr after a meal, acidity is reduced for 2 to 3 hrs o A second dose taken after a meal maintains reduced acidity for more than 4 hrs after the meal o The action of antacids occurs locally in the GI tract with minimal absorption, minimal metabolism o ALL antacids are contraindicated in the presence of severe abdominal pain of unknown cause, especially if accompanied by fever -HIGH SODIUM content: pts w/ HTN, CHF, marked renal failure, or on low-sodium diets need to use low sodium preparation -Concurrent administration with enteric-coated drugs, destroys the coating= alters absorption, ^ the risk for adverse effects -Administrations should be separated by at least 2 hours to decrease drug/drug interactions 1. Calcium based antacids: TUMS, Caltrate, Calcarb  Prescribed to treat calcium deficient states, i.e. chronic renal failure, post-menopause, and osteoporosis  Used to bind phosphates in CRF  Require Vitamin D for absorption from the GI tract  Excreted mainly in feces, 20% in urine  ADR: Contraindicated in the presence of hypercalcemia and renal calculi  Can cause constipation- increase bulk, fluids and mobility, stool softener  Administered 30min- 1hr on empty stomach or 3hr after meals  Should not be administered with food containing large amounts of oxalic acid (spinach, rhubarb), or phytic acid (bran, cereals), they decrease the absorption of calcium  Taking w/ foods containing phosphorus (milk, dairy) can lead to milk-alkali syndrome (N/V, confusion, headache).  Taking with acidic fruit juice improve absorption 2. Aluminum based: AlternaGEL, Amphojel, Mylanta  Inhibit smooth muscle contraction and slow gastric emptying  Used to bind phosphates in CRF  Not absorbable with routine use  Aluminum concentrated in the CNS  Bind with phosphate and excreted in feces  Prolonged use in patients with renal failure may result in dialysis osteomalacia o Aluminum deposits in bone and osteomalacia occurs  Elevated aluminum tissue levels contribute to the development of dialysis encephalopathy  Used to treat hyperphosphatemia in pts w/ renal failure & phosphate renal stone prevention  Can cause constipation- increase bulk, fluids and mobility, stool softener Aluminum is not easily removed by dialysis b/c it is bound to albumin & transferrin = do not cross dialysis membrane 3. Magnesium based: Milk of mag, Maalox, Mylanta  Can be used to treat magnesium deficiencies from malnutrition, alcoholism, or mag-depleting drugs  Contraindicated in patients with renal failure & used with caution in pts with renal insufficiency  Not absorbable with routine use  Excreted in the urine  Contraindicated in patients with renal failure, use with caution for patients with any degree of renal insufficiency o Malfunctioning kidney is unable to excrete magnesium and hypermagnesemia may result  Can cause diarrhea- increase fiber intake (Alkalosis may occur in renal impairment) Clinical Use and Dosing The malfunctioning kidney cannot excrete magnesium= hypermagnesemia may result  Rational drug selection o ANC, sodium content, and cost o Combination products with aluminum hydroxide and magnesium hydroxide have the highest ANC (use is moderate to severe disease  Monitoring o Serum phosphate, potassium, and calcium during chronic use o These drugs may cause increased serum calcium and decreased serum phosphate o Chronic magnesium hydroxide use may cause elevated Mg levels in patients with renal failure or the elderly with decreased renal function  Patient education o Take as prescribed, especially related to mealtimes o Take 1-3 hrs after meals and at bedtime o Chewable tablets chew thoroughly and drink half a glass of water o Shake suspensions before administration o Many drug interactions, separate doses by 2 hou [Show More]

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