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NURS 3631 Pharmacology FinaL Exam University of Houston

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Anti-inflammatory Drugs NSAIDS (ATI 279) – inhibits cyclooxygenase 1 & 2 : suppresses inflammation, relieves pain Ibuprofen Salicylates (Aspirin) Acetaminophen (Tylenol) Respiratory System ... Drugs 4 illnesses or diseases that impact URT and LRT? COPD, asthma, pneumonia Upper Respiratory Tract CARDIOVASCULAR!! CARDIAC PART 1 Classification for Hypertension (JNC 8/9) Sexual dysfunction is common in antihypertensive drug use Pregnancy: NO beta blockers in 1st trimester; NO ARBs or ACE Inhibitors *Diuretics Prototypes: Lasix (Black Box warning, makes you hypovolemic-really know BP and HR) -BB WARNING: water and electrolyte depletion and severe diuresis, makes you hypovolemic -TREATS PULM. EDEMA FROM HF, HYPERCALCEMIA, HTN • Hydrochlorothiazide – LESS risk of losing electrolytes bc of location -drug of choice for people with hypertension plus diabetes or plus heart failure -never do and ARB with an ACE together, it’s always either or -check apical pulse always beforehand for a full minute (hold medication if below 60 beats/min) BB WARNING- instruct pts not to stop the drug suddenly (1-2 weeks gradually), fatal arrhythmias -can exacerbate CHF DIGOXIN!!! (Lanoxin) Know every damn thing about it Most often used drug to treat heart failure as second line medication Digibind is an antidote for life-threatening overdose, decrease dose for mild overdose -dont give IM, give orally or IV slowly with dilution *treat hypokalemia before digoxin (3 hrs after IV), same with hyperkalemia. K has to be normal D-D Interactions: ALOT Class IV antiarrhythmics include two calcium-channel blockers: -closed angle glaucoma, head injuries, severe anemia DON’T TAKE IF YOU HAVE IT! OR SILDENAFIL!!! Prototype Summary: Nitroglycerin (Nitro-bid) *Isordil is for chronic angina, taken before chest pain begins in situations where angina is precipitated. *CAUTIONS (asthma, copd, dm, pvd, thyrotoxicosis) ARE DUE TO BB REMOVING THE BODY’S ABILITY TO RESPOND TO ACHIEVE HOMEOSTASIS GI Drugs *antibacterial drugs are used to eradicate H.pylori ex) Amoxicillin, metronidazole, tinidazole, tetracycline, bismuth Antacid (Gastric Acid Neutralizers) Pharmacodynamics – buffer HCL acid, raise pH, decrease injury to mucosal Lining -Too much antacids can lead to acid rebound; this is when the acid levels are are lowered and the stomach produces more gastrin and acid in response; basically just overcomes the effect of antacids Proton-Pump Inhibitor: block final step of acid production, reduce acid secretion by irreversibly inhibiting the enzyme that produces gastric acid -increase the risk for pneumonia Prostaglandins: Synthetic PGE, reduce bicarbonate and mucus production, decrease acid secretions *Misoprostol (Cytotec) and pregnancy Pharmacotherapeutics – prevention of NSAID, Aspirin induced ulcers [Show More]

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