UNIT 9 MN 553 Pharm Questions and complete Answers

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Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: Question options: A need to monitor drugs metabolized by 2D6 for toxicity Increased dosages needed of drugs metabolized by 2D6,... such as the selective serotonin reuptake inhibitors Decreased conversion of codeine to morphine by CYP 2D6 The need for lowered dosages of drugs, such as beta blockers correct answers Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors Rifampin is a nonspecific CYP450 inducer that may: Question options: Lead to toxic levels of rifampin and must be monitored closely Cause toxic levels of drugs, such as oral contraceptives, when administered Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure Cause nonspecific changes in drug metabolism correct answers Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure Inhibition of P-glycoprotein by a drug such as quinidine may lead to: Question options: Decreased therapeutic levels of quinidine Increased therapeutic levels of quinidine Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination correct answers Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: Question options: Toxic levels of warfarin building up Decreased response to w [Show More]

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