NUR 641E Midterm Study Guide Latest 2023

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Prodrug - An inactive drug dosage form that is converted to an active metabolite by various biochemical reactions once it is inside the body. -Cytochrome P450 -Ex. Aspirin, psilocybin, heroin Bi... oavailability - the rate at and the extent to which a nutrient is absorbed and used -Affected by route of administration and drug dosage -Drug clearance (rate drug leaves circulation) -Steady state concentration -Affected by chemical stability, solubility, and first pass Steady state (of a drug) - stable level of drug in the body, occurs in 5 half lives of the drug -rate of drug being added to system is equal to amount being eliminated from system Pharmacokinetics - The process by which drugs are absorbed, distributed within the body, metabolized, and excreted. -what the body does to the drug First pass - the fact that a medication in the GI tract passes through the liver before entering other organs does not - bioequivalence does/does not affect bioavailability Bioequivalence - relative therapeutic effectiveness of chemically equivalent drugs. Bioavailability (is affected by) - -chemical instability -solubility -first pass metabolism [Show More]

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