NBME Review, UWorld Review (1875 Questions with 100% Correct Answers) 181 Pages with COMPLETE SOLUTION

Document Content and Description Below

What can be associated with gastric cancer at the gastroesophageal junction? - ✔✔H. pylori What is esophagitis with linear ulcers associated with? - ✔✔CMV What is esophagitis with "punched-o... ut" ulcers associated with? - ✔✔HSV-1 What is esophagitis with white psuedomembrane? - ✔✔Candida What leads to acetaminophen toxicity? - ✔✔Reduced glutathione levels Why does reduced glutathione levels lead to acetaminophen toxicity? - ✔✔Glutathione is not there to bind to glutathione, which leads to a build up of the toxic metabolite, NAPQI Acetaminophen —> NAPQI (toxic) (+ glutathione) —> nontoxic metabolites What protein is important for trafficking proteins to lysosomes? - ✔✔Mannose 6 phosphate What occurs in the Golgi apparatus during cell trafficking? - ✔✔Golgi distributes proteins and lipids from ER to vesicles to go to the plasma membrane or lysosomes What happens if there's a defect with mannose 6-phosphate? - ✔✔The proteins will not be able to go to the lysosomes. They will be secreted extracellularly instead. This is called I cell disease What are physical characteristics caused from a loss in mannose 6 phosphate (I cell disease)? - ✔✔Coarse facial features, gingival hyperplasia, clouded corneas, restricted joint movements, claw hand deformities, kyphoscoliosis, and high plasma levels of lysosomal enzymesIs I-cell disease ( loss of mannose 6 phosphate) an inherited disease or is it sporadic? - ✔✔Inherited; defect in N-acetylglucosaminyl-1-phosphotransferase which prevents the formation of mannose 6 phosphate Would beta blockers be considered reversible or irreversible? - ✔✔Reversible Would beta blockers be considered to be a dose-dependent or dose independent medication? - ✔✔Dose dependent - the effects seen are affected by how much of drug is present What are endotoxins? - ✔✔toxins encoded in plasmids that are part of the structure of the bacteria, like lipopolysaccharides [Show More]

Last updated: 1 year ago

Preview 1 out of 181 pages