NBME 15 review

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Diabetic neuropathy symptoms Correct Answer: Numbness, tingling, ED, Urinary incontinence, Vision changes, Dizziness, Muscle weakness *Burning or electric pain* Glipizide Correct Answer: Sulfo... nylurea (stimulates endogenous insulin release) Close K+ channel in β-cell membrane = insulin release via ↑ Ca2+ influx. NF-κB Correct Answer: Activation occurs when it's inhibitor, I-κB, is phosphorylated by specific protein kinase (IKK) & degraded Insulin secretion Correct Answer: 1. Glucose binds Glut2 receptor on β-cells 2. Glucose oxidizes to ATP → closes K⁺ channels in cell membrane → depolarization of β-cells 3. Depolerizatino opens Ca²⁺ channels → ↑ intracellular [Ca²⁺] → [name of this card] [Show More]

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