WGU C785 Biochemistry Unit Exam Questions and Answers 100% Verified

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A final product of a four-step metabolic pathway serves as a noncompetitive inhibitor, binding to an enzyme in this pathway and temporarily turning off the pathway. Which enzyme is most likely to be... targeted by the inhibitor? The final enzyme in the pathway The first enzyme in the pathway Any enzyme in the middle of the pathway The second enzyme in the pathway Correct Answer- The first enzyme in the pathway The final product's structure is more unlike the substrate for the first enzyme in the pathway than any other, and thus the least likely to fit the active site of enzyme 1. A mutation in the beta-hemoglobin gene, which results in the replacement of the amino acid glutamate in position 6 with the amino acid valine, leads to the development of sickle cell anemia. The structures of glutamate and valine are shown below. If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so that the valine in position 6 was replaced with a different amino acid, which replacement for valine would be expected to have the best clinical outcome, in theory, for the patient? (Assume the valine can potentially be replaced with any amino acid other than glutamate.) Correct AnswerThe original amino acid in a healthy patient is glutamate, which is negatively charged. The mutated amino acid is valine, which is non-polar. Valine is causing sickle cell anemia. The best amino acid to replace valine so that the patient is healthy again would be the one most lik [Show More]

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