*NURSING > EXAM > Agents transmissibles non conventionnels 2023-2024 (All)

Agents transmissibles non conventionnels 2023-2024

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Agents transmissibles non conventionnels 2023-2024 ATNC - ANS-Agents Transmissibles Non Conventionnels Quels sont les groupes de l'ATCN ? - ANS-Il est divisé en deux groupes : - Les viroïdes : r... etrouvé uniquement dans le règne végétale ; - Les prions : protéines anormales. Qu'est-ce qu'un ATNC ? - ANS-Il s'agit d'un agent infectieux transmissible classé hors des microorganismes (comme les bactéries, champignons, parasites...) et des virus. Qu'est-ce qu'un viroïde ? - ANS-Il s'agit d'une particule virale simple, composée d'un seul ARN circulaire sans capside, à différencier des virus acapsidés puisque sa séquence n'encode pas de protéines. Il se fait répliqué en infectant une cellule hôte, tout en ayant des effets pathogènes comparables à ceux des virus encodant des protéines. Qu'est-ce qu'un prion ? - ANS-Il s'agit d'un agent pathogène constitué d'une protéine dont la conformation ou le repliement est anormal, et qui ne dispose pas d'acide nucléique (ADN ou ARN) pour support d'information, au contraire des agents infectieux tels que le virus, les bactéries ou les parasites. Créé en 1982 par Stanley PRUSINER, le terme "prion" est l'acronyme de PROteinaceous INfectious particule (particule protéique infectieuse) ou de PRoteinaceous Infectious ONly. Quelles sont les formes d'un prion ? - ANS-Il existe sous deux formes : - Une forme normale : glycloprotéine isoforme normale synthétisée par toutes les cellules, dont le système nerveux central, rapidement recyclée et appelée PrPc (PRotéine Prion Cellulaire) ; - Une conformation anormale : du fait de son repliement anormal, cette protéine échappe aux dégradations cellulaires, notamment les protéases, ce qui provoque une accumulation dans les structures cellulaires qui aboutit à des dégâts irréversibles, elle s'appelle PrPSc (PRotéine Prion SCrapie). Quelles sont les caractéristiques d'un prion ? - A [Show More]

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