Health Care > EXAM > NR 546 Week 3 Assignment; Antipsychotic Medications Table: (Solved) Guaranteed A+ Guide (All)
Drug name Indication Target symptoms: state if positive or negative effect Potency (if noted. receptor occupancy if noted ) Neurotransmitter(s) affected Half-life (T1/2), metabolism (CYP 450 e... nzyme) Notable side effects (associate to pathway or NT) Typical antipsychotics (conventional) Haloperidol Dopamine Receptor Antagonist Targets the symptoms of psychosis such as hallucinations and delusions. It can also be used to treat the tics and vocalizations of Tourette’s, as a second-line treatment for hyperactivity and severe behavioral problems in children. Works by blocking D2 receptors to reduce the positive symptoms of psychosis as well as possibly decreasing combative, explosive, and hyperactive behaviors. Its use in Tourette’s is related to blocking D2 receptors in the nigrostriatal pathway. Single dose: 12-38 hours Chronic use: 21 days Substrate CYP450 2D6 ● Akathisia, dystonia, and drug-induced parkinsonism- linked to blockade of D2 receptors in the striatum ● Tardive dyskinesia- linked to chronic blockade of D2 receptors in the striatum ● Galactorrhea/amenorrhea- linked to blocking of D2 receptors in the pituitary ● Neuroleptic-induced deficit syndromelinked to blockade of D2 receptors in the mesolimbic and mesocortical pathways ● Dizziness, hypotension, and syncope- linked to inadvertent blockade of alpha 1 adrenergic receptors Thioridazine Dopamine-Serotonin Receptor Antagonist Targets positive symptoms of psychosis such as hallucinations, delusions, aggression, and agitation. Commonly used for schizophrenic patients who fail to respond to other antipsychotic medications. [Show More]
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