Anti-Inflammatory DrugsWorkman & LaCharity: Understanding Pharmacology: Essentials for MedicationSafety, 2nd Edition

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BASIC CONCEPTS 1. Which stage of the inflammatory response involves capillary leak syndrome? a. Stage I b. Stage II c. Stage III d. Stage IV ANS: A The first stage of the inflammatory response ... involves white blood cells releasing chemical substances that act on blood vessels, making the pores larger so that fluid leaks out of the blood vessels into the damaged tissue. DIF: Cognitive Level: Remembering REF: p. 84 2. Which corticosteroid is applied topically to the skin? a. Betamethasone (Celestone) b. Triamcinolone (Kenalog) c. Dexamethosone (Decadron) d. Methylprednisolone (Solu-Medrol) ANS: B Betemethasone and dexamethosone are oral drugs. Methylprednisolone is a parenteral drug. Of the drugs on this list, only triamcinolone is applied as a topical drug. DIF: Cognitive Level: Remembering REF: p. 86 3. Which problem is a common side effect of long-term corticosteroid use? a. Acne b. Weight loss c. Redness and pain d. Low blood pressure ANS: A Corticosteroid use has many side effects including weight gain (not loss), retention of sodium and water leading to high blood pressure (not low blood pressure), and a lot of skin changes, including acne. Corticosteroids are used to reduce inflammation, so they eliminate redness and pain, they do not cause these side effects. DIF: Cognitive Level: Remembering REF: p. 87 4. Which side effect of corticosteroid therapy is permanent even after the drug is stopped? a. Difficulty sleeping b. Stretch marks TEST BANK FOR UNDERSTANDING PHARMACOLOGY 2ND EDITION BY WORKMAN NURSINGKING.COM #1 U.S NURSING TEST BANKS STORE clause N U R S I N G K I N G . C O M c. Weight gain d. Moon face ANS: B After corticosteroid therapy is stopped, many side effects resolve although this can take months to years. The sleep disturbance, weight gain, and moon-shaped face do go away over time. The stretch marks are permanent although they usually change from reddish-purple to silver over time so that they are less noticeable. DIF: Cognitive Level: Remembering REF: p. 87 5. Which anti-inflammatory drug is classified as a “COX-1” inhibitor? a. Hydrocortisone (Lanacort) b. Celecoxib (Celebrex) c. Zyleuton (Zyflo) d. Naproxen (Aleve) ANS: D Naproxen is the only COX-1 class anti-inflammatory drug on this list. Hydrocortisone is a corticosteroid. Celecoxib is a COX-2 inhibitor, not COX-1. Zyleuton is a leukotriene inhibitor. DIF: Cognitive Level: Remembering REF: p. 90 6. Which NSAID is a COX-2 inhibitor? a. Celecoxib (Celebrex) b. Ketorolac (Toradol) c. Aspirin (Bufferin) d. Ibuprofen (Motrin) ANS: A Celecoxib is the only drug from the COX-2 inhibitor class on this list. Aspirin, ibuprofen, and ketorolac are all COX-1 inhibitors. DIF: Cognitive Level: Remembering REF: p. 90 7. Which drug should NOT be given to children? a. Prednisone b. Ibuprofen (Motrin) c. Aspirin (Bufferin) d. Acetaminophen (Tylenol) ANS: C Aspirin is associated with a disorder known as Reye’s syndrome when given to a child who has a viral infection. It is not recommended to be given to anyone under 18 years of age. Prednisone, ibuprofen, and acetaminophen can be given to children if needed. DIF: Cognitive Level: Remembering REF: p. 93 8. Which drug should be avoided during the last 3 months of pregnancy? a. Prednisone b. Montelukast [Show More]

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