OCR Oxford Camtyidge and RSA Tuesday 17 May 2022 - Morning GCSE (9—1) Combined Science (Biology) A (Gateway Science) J250/01 Paper 1 (Foundation Tier) Time allowed: 1 hour 10 minutes

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INSTRUCTIONS • Use black ink. You can use an HB pencil, but only for graphs and diagrams. • Write your answer to each question in the space provided. If you need extra space use the lined pag... es at the end of this booklet. The question numbers must be clearly shown. • Answer all the questions. • Where appropriate, your answer should be supported with working. Marks might be given for using a correct method, even if your answer is wrong. INFORMATION • The total mark for this paper is 60. • The marks for each question are shown in brackets [ ]. • Quality of extended response will be assessed in questions marked with an asterisk (*). • This document has 20 pages. ADVICE • Read each question carefully before you start your answer. You must have: • a ruler (cm/mm) You can use: • a scientific or graphical calculator • an HB pencil Tuesday 17 May 2022 – Morning GCSE (9–1) Combined Science (Biology) A (Gateway Science) J250/01 Paper 1 (Foundation Tier) Time allowed: 1 hour 10 minutes F 2 © OCR 2022 SECTION A Answer all the questions. You should spend a maximum of 20 minutes on this section. Write your answer to each question in the box provided. 1 Which part of the cell provides a selective barrier to molecules entering the cell? A Cell membrane B Cell wall C Cytoplasm D Plasmid Your answer [1] 2 A microscope has a ×10 eyepiece lens and a ×40 objective lens. What is its magnification? A ×10 B ×40 C ×50 D ×400 Your answer [1] 3 Which two terms describe the structure of DNA? A Monomer and double helix B Monomer and triple helix C Polymer and double helix D Polymer and triple helix Your answer [1] 3 © OCR 2022 Turn over 4 The diagram shows a model of a protein molecule. P Which substance is labelled P in the diagram? A Amino acid B Fatty acid C Glucose D Glycerol Your answer [1] 5 The diagram shows the changes in female hormones during the menstrual cycle. 2 Hormone concentration in the blood 1 3 4 5 6 7 8 9 10 11 12 13 28 day cycle 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 A B C D Ovulation occurs Which line, A, B, C or D, represents FSH? Your answer [1] 4 © OCR 2022 6 Which statement describes a substance being transported into the human body from the outside? A Carbon dioxide diffuses into the blood from the cells. B Food molecules diffuse into the liver from the blood. C Oxygen diffuses into the blood from the air. D Urea diffuses into the blood from the liver. Your answer [1] 7 Why do root hair cells require large numbers of mitochondria? A For the uptake of minerals by active transport. B For the uptake of water by active transport. C For the uptake of minerals by osmosis. D For the uptake of water by osmosis. Your answer [1] 8 Which statement is true for type 1 diabetes and false for type 2 diabetes? A The body stops responding to insulin, insulin injections are needed. B The body stops responding to insulin, insulin injections are not needed. C The pancreas stops making insulin, insulin injections are needed. D The pancreas stops making insulin, insulin injections are not needed. Your answer [1] 5 © OCR 2022 Turn over 9 Which statement is true of both adult and embryonic stem cells? A They are in all adult and embryonic tissues. B They are only used to make blood cells. C They can divide by mitosis. D They cannot differentiate. Your answer [1] 10 The diagram shows the root tip of a plant. D C B A Which label, A, B, C or D, identifies the position of stem cells in the root tip? Your answer [1] 6 © OCR 2022 SECTION B Answer all the questions. 11 (a) The diagram shows the central nervous system (CNS). Complete the sentence to describe the structure of the CNS. Use the diagram. The CNS is made up of the ......................................... and the ........................................ cord. [2] (b) (i) Hot objects can burn your skin. Removing your hand from a hot object is a reflex action. The response is a reflex action because it is controlled by a reflex arc. Suggest two other reasons why the response is a reflex action. 1 ........................................................................................................................................ 2 ........................................................................................................................................ [2] 7 © OCR 2022 Turn over (ii) Draw lines to connect each part of the reflex arc to its correct function when responding to a hot object. Part Function muscles detects the hot object motor neurone move the hand away receptor in skin carries electrical impulses to the CNS sensory neurone carries electrical impulses to the muscles [3] (c) A student uses a computer program to measure the reaction times of their friends. The table shows their results. Friend Sex of friend Age of friend Time spent each week playing computer games (hours) Reaction time (s) A male 14 5 0.34 B male 14 7 0.29 C female 15 6 0.26 D female 14 15 0.24 E male 15 3 0.27 (i) Identify the median reaction time for the five friends. Median reaction time = ....................................................... s [1] (ii) Calculate the mean reaction time for the five friends. Mean reaction time = ....................................................... s [2] (iii) Use the data in the table to suggest one reason why friend D has the fastest reaction time. ........................................................................................................................................... ...................................................................................................................................... [1] 8 © OCR 2022 (d) Adrenaline is a hormone that speeds up reaction times. Describe the typical features of hormonal coordination such as adrenaline in the body. ................................................................................................................................................... ................................................................................................................................................... ................................................................................................................................................... .............................................................................................................................................. [2] 9 © OCR 2022 Turn over BLANK PAGE PLEASE DO NOT WRITE ON THIS PAGE 10 © OCR 2022 12 (a) Fig. 12.1 shows a model of the lock and key hypothesis for enzy [Show More]

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