PHAR 742 -Basic Pharmacokinetics Final exam 2, Part A(Final Exam keys)

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1. Which of the following statements is correct for measurement of drug concentration? a) Chromatographic methods for drug analysis are less discriminating since they cannot separate the drug from t... he interfering materials. b) Fluorescence immunoassay (FIA) is a chromatographic method. c) Drug in feces reflects only the unabsorbed drug after oral dose. d) Plasma is obtained by allowing blood to clot and centrifuging to remove cells and some proteins. e) Both urine and feces are important in mass balance study. 2. The zero order rate constant of theophylline release from a 300 mg sustained release formulation is 15 mg/hr. How much time is required for the release of 80% theophylline from the dosage form? a) 4 hour b) 12 hour c) 16 hour d) 20 hour e) 27 hour 3. First order elimination of drugs from the body means that the rate of decrease in plasma drug concentration ______________________________________. a) is independent of drug concentration in the plasma b) is constant c) changes with time but is not dependent on the plasma drug concentration. d) changes with time and is dependent on the plasma drug concentration e) follows Michaelis-Menten kinetics 4. One compartment open model means ____________________________. a) one exponential term describes decreasing plasma concentration of the drug b) the drug is restricted to extracellular fluid c) the drug does not penetrate tissues d) the elimination is a zero-order process e) the drug concentration in blood equilibrate slowly with drug concentration in extravascular tissues Page 2 of 9 5. A 120 mg dose of propranolol was given to a 42-year old, 72-kg patient by single IV bolus injection. The serum concentration immediately after the dose was 4.5 mg/L. What is the apparent volume of distribution of propranolol in this patient? a) 1.7 mg/kg b) 9.2 mg/kg c) 12.6 L d) 16.0 L/kg e) 26.7 L 6. Plasma level just after an intravenous dose of a drug is 12.3 g/mL in a patient. The concentration drops to 5.0 g/mL after 6 hr. What is the elimination rate constant, k of the drug in this patient assuming a one-compartment model? a) 0.02 hr1 b) 0.06 hr1 c) 0.11 hr1 d) 0.15 hr1 e) 0.27 hr1 [Show More]

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