NR-507-2021- Advanced Pathophysiology -Week 8 Final Exam study Guide

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endometrial cycle and the occurrence of ovulation- the menstrual cycle consist of three phases: the follicular/proliferative phase (postmenstrual), followed by the luteal/secretory phase (premenstru... al), and the ischemic/menstrual phase. *Ovarian hormones control the uterine (endometrial) events of the menstrual cycle. During the follicular/proliferative phase of the ovarian cycle estrogen produced by the follicle causes the endometrium to proliferate (proliferative phase) and induces the LH surge and progesterone production in the granulosa layer. During the luteal/secretory phase, estrogen maintains the thickened endometrium, and progesterone causes it to develop blood vessels and secretory glands (secretory phase). As the corpus luteum “starved” endometrium degenerates and sloughs off, causing menstruation, the ischemic/menstrual phase. uterine prolapse- the descent of the cervix or entire uterus into the vaginal canal due to weakened pelvic fascia and musculature and poor support from the vaginal muscles and fascia. polycystic ovarian syndrome- most common cause of anovulation and ovulatory dysfunction in women. Defined as having at least two of the following three features: irregular ovulation, elevated levels of androgens (e.g., testosterone), and the appearance of polycystic ovaries on ultrasound. PCOS is associated with metabolic dysfunction, including dyslipidemia, insulin resistance, and obesity. One of the most common endocrine disturbances affecting women, especially young women, and is a leading cause of infertility in the U.S. Strong genetic component to PCOS, various features of the syndrome may be inherited. PCOS patients are three times as likely to have insulin resistance, higher for obese women. Tend to have increased leptin levels. Symptoms within 2 years of puberty & include: dysfunctional bleeding or amenorrhea, hirsutism, acne, acanthosis nigricans, and infertility. 60% are obese. Increased risk for gestational DM, pregnancy-induced HTN, preterm birth, and perinatal mortality. [Show More]

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