Exam 1 pharm Study guide.

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Parkinsonism  Pathophysiology o Lack of Dopamine, Low Movement, High Acetylcholine o Chronic neurologic disorder o Imbalance of the neurotransmitters dopamine (DA) and acetylcholine (ACh) o ... Marked by degeneration of neurons of the extrapyramidal motor tract o Reason for the degeneration of neurons is unknown. — Characteristics o Tremors of head and neck o Rigidity (increased muscle tone) o Bradykinesia (slow movement) o Postural changes — Head and chest thrown forward o Shuffling walk o Lack of facial expression o Pill-rolling motion of hands — Treatment regimen No cure, only management of symptoms Inhibit release of acetylcholine o Anticholinergics - sympathetic — Block cholinergic receptors o Dopaminergics — Convert to dopamine o Dopamine agonists — Stimulate dopamine receptors o MAO-B inhibitors — Inhibit MAO-B enzyme that interferes with dopamine o COMT inhibitors — Inhibit COMT enzyme that inactivates dopamine [Show More]

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