NR 566 Midterm Exam (Latest 2023 - 2024) New Full Questions and Answers ( Included ) 100% Correct

Document Content and Description Below

1. Bioavailability of bisphosphonate drugs and appropriate patient education- : Histamine2 blocking agents double alendronate bioavailability, but the impact isunknown. Aspirin may decrease the bioa... vailability of tiludronate by up to 50% when taken 2 hours after the tiludronate. Although indomethacin increases the bioavailability of tiludronate by 2- to 4-fold, the bioavailability is not significantly altered by diclofenac; therefore, each NSAID must be considered individually. 2. Adverse effects associated with long-term use of bisphonates: Etidronate has also been associated with fractures in patients with Paget's disease when they are given high doses or when therapy lasted longer than 6 months. These patients must be carefully monitored with x-rays and laboratory work to assess forthese lesions.The development of a rare form of subtrochanteric femur fracture in non-Paget's patients using bisphosphonates is under close scrutiny and has contributed to movement away fromosteopenia prevention care to only osteoporosistherapy (FDA, 2010a). 3. Specifics about administration and education regarding pancreatic en- zymes: All doses are taken immediately before or with meals or snacks with a fattycomponent. Fruit, hard candy, fruit juice like drinks, tea or coffee, or popsicles do not require enzymes (CFF, 2009). Capsules may be opened and sprinkled on food.Capsules with enteric-coated beads should not be chewed. They may be sprinkledon soft acidic food that is not hot and that can be swallowed without chewing,such asapplesauce or gelatin. Swallow immediately because the proteolytic enzymes mayirritate the mucosa. Following with a glass of water or juice or eating immediately after taking the drug helps to ensure that the medication is swallowed and does notremain in contact with the mouth and esophagus for long periods. Pancrelipase is destroyed by acid. Proton pump inhibitors, sodium bicarbonate, or aluminum-basedantacids may be used with preparations without enteric coating to neutralize gastricpH. Calcium- and magnesium-based antacids should not be used for this purpose because they interfere with drug action. Enteric-coated beads are designed to withstand the acid pH of the stomach. Enteric-coated formulations should not be mixed with alkaline food or the coating will be destroyed. 4. Common adverse effects with aromatase inhibitors: Adverse effects for the drug class include various pain syndromes, vertigo, insomnia resulting in daytime sleepiness and confusion, increased risk of blood clots, and hair loss.A key concernis the loss of bone mass. Bone loss can be significant when considering the concurrent osteoporotic risks of postmenopause. Closer monitoring is required. Allpatients should be on calcium and vitamin D supplementation. A relative leukopeniacan occur, but the incidence of viral and bacteria infections is not considered greaterthan matched groups (about 10%). Hypertension occurs in 10% of patients. A life-threatening increase in blood clotting can result in MI, stroke, or pulmonaryembolus. Hot flashes can be intense. 5. Drugs associated risk for bone loss which should be monitored: Aromataseinhibitors Thyroid hormones [Show More]

Last updated: 1 week ago

Preview 1 out of 17 pages