Use of Karotype Analysis,Biology Essay

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Use Of Karyotype Analysis Biology Essay Abstract A complete set of metaphase chromosomes is called a karyotype. It is widely used to detect the chromosomal abnormalities that are related to the gen... etic diseases and various type of cancer. As the biomedical science advances, various kinds of techniques are introduced to analyze the human karyotype. These karyotype analyse are widely used in genetic counselling to minimize the risk of having unfortunate abnormalities that can cause serious limitation on quality of life. So, nowadays individual and families are realized the necessity to implement the genetic testing. Introduction In genetic counselling, knowledge of karyotype analysis is greatly used to determine the heritable diseases including cancer. Moreover, pedigree construction based on Mendelian principles was used in days gone by the determinable pattern of inheritance. In recent years, FISH (fluorescence in situ hybridization), PCR (polymerase chain reaction), CGH (comparative genomic hybridization) and SNP (single nucleotide polymorphism) arrays have been developed and hold a promising future for human genetics. Among them FISH is the most currently diagnostic tool for the various chromosomal aberrations that can be visible in karyotype analysis. The most tested chromosomes are 13, 18, 21, 22, X and Y that account for 85% of chromosomal abnormalities (Rodrigo et al., 2010). But now, genetic scientists have carried out all the approaches towards chromosome analysis. On the other hand, with the high risk society is greatly interested to do pre pregnancy counselling to reduce the heritable defective genes for the next generation. Therefore, use of karyotype analysis has [Show More]

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