BioChem C785 / Biochemistry Unit 4

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Biochemistry – C785 Unit 4 Quiz 1. Which of the following could be a potential ramification of a defective nucleotide excision repair (NER) pathway? a. Thymine dimers would accumulate and increa... se the probability of developing skin cancer. 2. A patient has received a large dose of ionizing radiation at his place of employment. Which scenario is accurate? a. Double-stranded DNA breaks are being repaired by nonhomologous end joining, without the use of a homologous template. 3. Immediately following transcription, mRNA must be processed before it is transported to the cytoplasm to undergo translation. Which statement correctly describes mRNA processing? a. Introns are spliced out and exons are connected to produce a mature mRNA sequence. 4. A point mutation has altered the amino acid sequence of a neuronal tau protein, causing serine (Ser) at position 202 to be mutated to proline (Pro). Which set of codons below corresponds to this mutation? a. TCT to CCT 5. Which of the following is required for DNA polymerase to replicate template DNA in PCR? a. DNA primers 6. A portion of the HLA gene and its associated amino acid sequence are shown below. If cytosine is deleted from codon 101, what will be the resulting amino acid sequence? This study source was downloaded by 100000831988016 from CourseHero.com on 06-02-2022 16:00:00 GMT -05:00 https://www.coursehero.com/file/55586688/Biochemistry-Unit-4-Quizdocx/ a. Glu Met Leu 7. Inheriting mutations in the BRCA-1 or BRCA-2 gene can increase an individual's likelihood of developing breast cancer or ovarian cancer. How can PCR be used to assess an individual's susceptibility to developing these cancers? a. PCR primers can be engineered to flank the mutation of interest in the BRCA-1 and BRCA-2 genes, and the PCR product can be sequenced to look for mutations. 8. Which template DNA sequence would result in the amino acid proline (Pro)? a. 5' - TGG - 3' 9. Legumain is an enzyme that is overexpressed in neurons in response to traumatic brain injury (TBI). How does TBI trigger an increase in the expression of the gene that codes for legumain? a. Nucleosomes are more widely spaced, exposing the legumain gene. 10. Which of the following mRNA sequences can be translated into a peptide sequence containing two amino acids? This study source was downloaded by 100000831988016 from CourseHero.com on 06-02-2022 16:00:00 GMT -05:00 https://www.coursehero.com/file/55586688/Biochemistry-Unit-4-Quizdocx/ a. 5' - GAU CGA UAG UGG - 3' 11. What is the mRNA sequence that would result from this coding DNA sequence: 5’ – CAG TTA GAT TCA – 3’? a. 5' - CAG UUA GAU UCA - 3' [Show More]

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