Pharmacology EDAPT - Glucocorticoid (prednisone)

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Pharmacology EDAPT - Glucocorticoid (prednisone) prednisone is the most commonly prescribed oral glucocorticoid - ✔✔oral prednisone is a(n) intermediate acting systemic - ✔✔intermediate Un... like other glucocorticoids, prednisone has minimal impacts on . - ✔✔fluid-electrolyte balance Like the other intermediate-acting glucocorticoids, the half-life of prednisone is __________ giving it a longer duration of action than short-acting corticosteroids. - ✔✔18-36 hours Which terms describe prednisone? Select all that apply. - ✔✔Systemic Synthetic Intermediate-acting prednisone is a ____ corticosteroid prednisolone is the _____ form of prednisone converted by the liver - ✔✔solid liquid Why should prednisone be used cautiously with immunocompromised individuals? - ✔✔prednisone is an immunosuppressant Why is it important to taper the daily dosage of prednisone with long-term use? Select all that apply. - ✔✔HPA axis time adrenal suppression Which statements are true regarding long-term use of prednisone (corticosteroids)? Select all that apply. - ✔✔After as little as 1 week of use, abrupt discontinuation of prednisone can result in adrenal suppression. The presence of corticosteroid drugs over a long period of time causes the body's own (endogenous) corticosteroid production to stop. Which of the following patients is the MOST at risk for developing adrenal suppression and subsequent hypoadrenal crisis if this dose is stopped abruptly? - ✔✔A patient taking prednisone 50 mg/day for the last 3 months Which statement is true regarding the indications of prednisone use? - ✔✔Prednisone, unlike other corticosteroids, has only minimal mineralocorticoid effects (in addition to glucocorticoid effects) and therefore it is used in conjunction with a mineralocorticoid to treat chronic respiratory illnesses such as asthma Which of the following are glucocorticoid brand names for prednisone? - ✔✔prednisolone, triamcinolone, methylprednisolone, and hydrocortisone Choose the correct word(s) to complete these sentences regarding prednisone. - ✔✔prednisone is a SYNTHETIC corticosteroid prednisone is a GLUCOCORTICCOID prednisone is only administered SYSTEMICALLY prednisone is only administered ORALLY prednisone is a(n) INTERMEDIATE ACTING How does prednisone differ from the other three intermediate-acting glucocorticoids? - ✔✔Has minimal impact on fluid-electrolyte balance Prednisone, as with all corticosteroids, is classified as a pregnancy category C drug. What does this mean? - ✔✔it can be secreted in breast milk and should be used cautiously with breastfeeding. Considering the action of glucocorticoids, choose the types of medications that should be used cautiously with prednisone and match them to the associated reason for this caution. - ✔✔Anticoagulation: bloodthinners Prednisone...: immunosuppressants Increase the half life: oral contraceptives Reduction in hypoglycemic effects: antihypertensives Additive GI effects: NSAIDS [Show More]

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